feat: implement biomarker models, reference rules, and data seeding logic

backend/seed.yaml

@@ -0,0 +1,46 @@
+# Seed Data for zhealth
+# Run `zhealth seed` to sync this data to the database.
+
+roles:
+  - name: admin
+    description: Full access to everything
+  - name: user
+    description: Can manage their own biomarker data
+  - name: reader
+    description: Read-only access to analytics
+
+biomarker_categories:
+  - name: blood
+    description: Blood cell counts and hemogram markers
+  - name: cardiac
+    description: Heart and cardiovascular markers
+  - name: electrolytes
+    description: Electrolyte balance markers
+  - name: hormones
+    description: Hormone and steroid levels
+  - name: inflammation
+    description: Inflammation and arthritis markers
+  - name: lipid_panel
+    description: Cholesterol and lipid markers
+  - name: liver
+    description: Liver function markers
+  - name: metabolic
+    description: Metabolic and diabetes markers
+  - name: minerals
+    description: Essential mineral levels
+  - name: renal
+    description: Kidney function markers
+  - name: thyroid
+    description: Thyroid function markers
+  - name: toxicology
+    description: Toxic element levels
+  - name: urine
+    description: Urinalysis markers
+  - name: vitamins
+    description: Vitamin levels
+  - name: vitals
+    description: Vital signs
+  - name: body
+    description: Body measurements
+  - name: activity
+    description: Physical activity metrics

backend/src/cli.rs

@@ -14,10 +14,11 @@ pub struct Args {
 pub enum Command {
     Serve(ServeCommand),
     Migrate(MigrateCommand),
+    Seed(SeedCommand),
     Version(VersionCommand),
 }
 
-/// Start the server (runs migrations first)
+/// Start the server (runs migrations and seed first)
 #[derive(FromArgs)]
 #[argh(subcommand, name = "serve")]
 pub struct ServeCommand {}
@@ -27,6 +28,11 @@ pub struct ServeCommand {}
 #[argh(subcommand, name = "migrate")]
 pub struct MigrateCommand {}
 
+/// Sync seed data from seed.yaml
+#[derive(FromArgs)]
+#[argh(subcommand, name = "seed")]
+pub struct SeedCommand {}
+
 /// Show version information
 #[derive(FromArgs)]
 #[argh(subcommand, name = "version")]

backend/src/db.rs

@@ -4,7 +4,7 @@ use sea_orm::{ConnectionTrait, Database, DatabaseConnection, DbBackend, DbErr, S
 use sea_orm::sea_query::SqliteQueryBuilder;
 
 use crate::config::Config;
-use crate::models::bio::{biomarker_entry, biomarker_type};
+use crate::models::bio::{biomarker, biomarker_category, biomarker_entry, biomarker_reference_rule};
 use crate::models::user::{role, session, user};
 
 /// Connect to the SQLite database.
@@ -26,10 +26,12 @@ pub async fn run_migrations(db: &DatabaseConnection) -> Result<(), DbErr> {
 
     // Create table statements (order matters for foreign keys)
     let statements = vec![
-        schema.create_table_from_entity(role::Entity),        // roles first
-        schema.create_table_from_entity(user::Entity),        // users references roles
+        schema.create_table_from_entity(role::Entity),
+        schema.create_table_from_entity(user::Entity),
         schema.create_table_from_entity(session::Entity),
-        schema.create_table_from_entity(biomarker_type::Entity),
+        schema.create_table_from_entity(biomarker_category::Entity),
+        schema.create_table_from_entity(biomarker::Entity),
+        schema.create_table_from_entity(biomarker_reference_rule::Entity),
         schema.create_table_from_entity(biomarker_entry::Entity),
     ];
 

backend/src/main.rs

@@ -2,6 +2,7 @@ mod cli;
 mod config;
 mod db;
 mod models;
+mod seed;
 
 use axum::{routing::get, Router};
 use std::net::SocketAddr;
@@ -28,6 +29,22 @@ async fn main() -> anyhow::Result<()> {
             db::run_migrations(&db).await?;
             tracing::info!("Migrations complete.");
         }
+        Command::Seed(_) => {
+            let config = config::Config::load("config.yaml")?;
+            init_logging(&config);
+
+            let db = db::connect(&config).await?;
+
+            tracing::info!("Syncing seed data...");
+            let seed_data = seed::SeedData::load("seed.yaml")?;
+            seed::sync_seed_data(&db, &seed_data).await?;
+            
+            tracing::info!("Syncing biomarker data...");
+            let biomarker_data = seed::BiomarkerSeedData::load("seed_biomarkers.yaml")?;
+            seed::sync_biomarker_data(&db, &biomarker_data).await?;
+            
+            tracing::info!("Seed data synced.");
+        }
         Command::Serve(_) => {
             let config = config::Config::load("config.yaml")?;
             init_logging(&config);
@@ -38,8 +55,19 @@ async fn main() -> anyhow::Result<()> {
             db::run_migrations(&db).await?;
             tracing::info!("Migrations complete.");
 
+            // Sync seed data
+            tracing::info!("Syncing seed data...");
+            let seed_data = seed::SeedData::load("seed.yaml")?;
+            seed::sync_seed_data(&db, &seed_data).await?;
+            
+            tracing::info!("Syncing biomarker data...");
+            let biomarker_data = seed::BiomarkerSeedData::load("seed_biomarkers.yaml")?;
+            seed::sync_biomarker_data(&db, &biomarker_data).await?;
+            
+            tracing::info!("Seed data synced.");
+
             // Start server
-            tracing::info!("Starting zhealth-backend...");
+            tracing::info!("Starting zhealth...");
             let app = Router::new()
                 .route("/", get(root))
                 .route("/health", get(health_check));

backend/src/models/bio/biomarker.rs

@@ -0,0 +1,66 @@
+//! Biomarker entity - individual biomarker definitions.
+
+use sea_orm::entity::prelude::*;
+use serde::{Deserialize, Serialize};
+
+#[derive(Clone, Debug, PartialEq, Eq, DeriveEntityModel, Serialize, Deserialize)]
+#[sea_orm(table_name = "biomarkers")]
+pub struct Model {
+    #[sea_orm(primary_key)]
+    pub id: i32,
+
+    /// Foreign key to biomarker_categories (our internal category for analytics)
+    pub category_id: i32,
+
+    /// Biomarker name: HEMOGLOBIN, LDL CHOLESTEROL, etc.
+    #[sea_orm(unique)]
+    pub name: String,
+
+    /// Lab report category: HEMOGRAM, LIPID, LIVER, etc.
+    pub test_category: String,
+
+    /// Unit of measurement: g/dL, mg/dL, etc.
+    pub unit: String,
+
+    /// Testing methodology: ICP-MS, HPLC, Enzymatic, etc.
+    pub methodology: Option<String>,
+
+    #[sea_orm(column_type = "Text", nullable)]
+    pub description: Option<String>,
+}
+
+#[derive(Copy, Clone, Debug, EnumIter, DeriveRelation)]
+pub enum Relation {
+    #[sea_orm(
+        belongs_to = "super::biomarker_category::Entity",
+        from = "Column::CategoryId",
+        to = "super::biomarker_category::Column::Id"
+    )]
+    Category,
+
+    #[sea_orm(has_many = "super::biomarker_entry::Entity")]
+    Entries,
+
+    #[sea_orm(has_many = "super::biomarker_reference_rule::Entity")]
+    ReferenceRules,
+}
+
+impl Related<super::biomarker_category::Entity> for Entity {
+    fn to() -> RelationDef {
+        Relation::Category.def()
+    }
+}
+
+impl Related<super::biomarker_entry::Entity> for Entity {
+    fn to() -> RelationDef {
+        Relation::Entries.def()
+    }
+}
+
+impl Related<super::biomarker_reference_rule::Entity> for Entity {
+    fn to() -> RelationDef {
+        Relation::ReferenceRules.def()
+    }
+}
+
+impl ActiveModelBehavior for ActiveModel {}

backend/src/models/bio/biomarker_category.rs

@@ -0,0 +1,32 @@
+//! BiomarkerCategory entity - categories for grouping biomarkers.
+
+use sea_orm::entity::prelude::*;
+use serde::{Deserialize, Serialize};
+
+#[derive(Clone, Debug, PartialEq, Eq, DeriveEntityModel, Serialize, Deserialize)]
+#[sea_orm(table_name = "biomarker_categories")]
+pub struct Model {
+    #[sea_orm(primary_key)]
+    pub id: i32,
+
+    /// Category name: body, vitals, activity, lipid_panel, metabolic, vitamins, hormones
+    #[sea_orm(unique)]
+    pub name: String,
+
+    #[sea_orm(column_type = "Text", nullable)]
+    pub description: Option<String>,
+}
+
+#[derive(Copy, Clone, Debug, EnumIter, DeriveRelation)]
+pub enum Relation {
+    #[sea_orm(has_many = "super::biomarker::Entity")]
+    Biomarkers,
+}
+
+impl Related<super::biomarker::Entity> for Entity {
+    fn to() -> RelationDef {
+        Relation::Biomarkers.def()
+    }
+}
+
+impl ActiveModelBehavior for ActiveModel {}

backend/src/models/bio/biomarker_entry.rs

@@ -1,4 +1,5 @@
-//! BiomarkerEntry entity - user-logged biomarker values.
+//! BiomarkerEntry entity - user biomarker measurements.
+//! Uses composite primary key: (biomarker_id, user_id, measured_at)
 
 use sea_orm::entity::prelude::*;
 use serde::{Deserialize, Serialize};
@@ -6,18 +7,22 @@ use serde::{Deserialize, Serialize};
 #[derive(Clone, Debug, PartialEq, DeriveEntityModel, Serialize, Deserialize)]
 #[sea_orm(table_name = "biomarker_entries")]
 pub struct Model {
-    #[sea_orm(primary_key)]
-    pub id: i32,
+    /// Foreign key to biomarkers table (part of composite PK)
+    #[sea_orm(primary_key, auto_increment = false)]
+    pub biomarker_id: i32,
 
+    /// Foreign key to users table (part of composite PK)
+    #[sea_orm(primary_key, auto_increment = false)]
     pub user_id: i32,
-    pub biomarker_type_id: i32,
+
+    /// Date/time of measurement (part of composite PK)
+    #[sea_orm(primary_key, auto_increment = false)]
+    pub measured_at: DateTime,
 
     /// The measured value
     pub value: f64,
 
-    /// Date when the measurement was taken
-    pub measured_at: Date,
-
+    /// Optional notes about this measurement
     #[sea_orm(column_type = "Text", nullable)]
     pub notes: Option<String>,
 
@@ -26,19 +31,25 @@ pub struct Model {
 
 #[derive(Copy, Clone, Debug, EnumIter, DeriveRelation)]
 pub enum Relation {
+    #[sea_orm(
+        belongs_to = "super::biomarker::Entity",
+        from = "Column::BiomarkerId",
+        to = "super::biomarker::Column::Id"
+    )]
+    Biomarker,
+
     #[sea_orm(
         belongs_to = "crate::models::user::user::Entity",
         from = "Column::UserId",
         to = "crate::models::user::user::Column::Id"
     )]
     User,
+}
 
-    #[sea_orm(
-        belongs_to = "super::biomarker_type::Entity",
-        from = "Column::BiomarkerTypeId",
-        to = "super::biomarker_type::Column::Id"
-    )]
-    BiomarkerType,
+impl Related<super::biomarker::Entity> for Entity {
+    fn to() -> RelationDef {
+        Relation::Biomarker.def()
+    }
 }
 
 impl Related<crate::models::user::user::Entity> for Entity {
@@ -47,10 +58,4 @@ impl Related<crate::models::user::user::Entity> for Entity {
     }
 }
 
-impl Related<super::biomarker_type::Entity> for Entity {
-    fn to() -> RelationDef {
-        Relation::BiomarkerType.def()
-    }
-}
-
 impl ActiveModelBehavior for ActiveModel {}

backend/src/models/bio/biomarker_reference_rule.rs

@@ -0,0 +1,72 @@
+//! BiomarkerReferenceRule entity - flexible reference rules for biomarker interpretation.
+//! Supports: ranges, scales, age-based, sex-based, time-based, and life-stage-based references.
+
+use sea_orm::entity::prelude::*;
+use serde::{Deserialize, Serialize};
+
+#[derive(Clone, Debug, PartialEq, DeriveEntityModel, Serialize, Deserialize)]
+#[sea_orm(table_name = "biomarker_reference_rules")]
+pub struct Model {
+    #[sea_orm(primary_key)]
+    pub id: i32,
+
+    /// Foreign key to biomarkers
+    pub biomarker_id: i32,
+
+    /// Rule type: "range" (normal range), "scale" (interpretation scale), "expected" (qualitative)
+    pub rule_type: String,
+
+    /// Sex filter: "any", "male", "female"
+    #[sea_orm(default_value = "any")]
+    pub sex: String,
+
+    /// Age range lower bound in years (NULL = no lower bound)
+    pub age_min: Option<i32>,
+
+    /// Age range upper bound in years (NULL = no upper bound)
+    pub age_max: Option<i32>,
+
+    /// Time of day for diurnal variation tests (e.g., "08:00", "16:00")
+    pub time_of_day: Option<String>,
+
+    /// Life stage: "prepubertal", "adult", "follicular", "luteal", "postmenopausal", "pregnancy"
+    pub life_stage: Option<String>,
+
+    /// Value range lower bound (NULL = no lower bound, e.g., "<15")
+    pub value_min: Option<f64>,
+
+    /// Value range upper bound (NULL = no upper bound, e.g., ">=90")
+    pub value_max: Option<f64>,
+
+    /// Expected value for qualitative tests: "ABSENT", "NEGATIVE", "PALE YELLOW"
+    pub expected_value: Option<String>,
+
+    /// Label for this rule: "Normal", "Deficiency", "Kidney Failure", etc.
+    pub label: String,
+
+    /// Severity level: 0=normal, 1=mild, 2=moderate, 3=severe, 4=critical
+    #[sea_orm(default_value = 0)]
+    pub severity: i32,
+
+    /// Sort order for scales (1, 2, 3...) to ensure correct order
+    #[sea_orm(default_value = 0)]
+    pub sort_order: i32,
+}
+
+#[derive(Copy, Clone, Debug, EnumIter, DeriveRelation)]
+pub enum Relation {
+    #[sea_orm(
+        belongs_to = "super::biomarker::Entity",
+        from = "Column::BiomarkerId",
+        to = "super::biomarker::Column::Id"
+    )]
+    Biomarker,
+}
+
+impl Related<super::biomarker::Entity> for Entity {
+    fn to() -> RelationDef {
+        Relation::Biomarker.def()
+    }
+}
+
+impl ActiveModelBehavior for ActiveModel {}

backend/src/models/bio/biomarker_type.rs

@@ -1,43 +0,0 @@
-//! BiomarkerType entity - the knowledge base of available biomarkers.
-
-use sea_orm::entity::prelude::*;
-use serde::{Deserialize, Serialize};
-
-#[derive(Clone, Debug, PartialEq, DeriveEntityModel, Serialize, Deserialize)]
-#[sea_orm(table_name = "biomarker_types")]
-pub struct Model {
-    #[sea_orm(primary_key)]
-    pub id: i32,
-
-    #[sea_orm(unique)]
-    pub name: String,
-
-    /// Category: lipid_panel, metabolic, vitamins, hormones, etc.
-    pub category: String,
-
-    /// Unit of measurement: mg/dL, mmol/L, ng/mL, etc.
-    pub unit: String,
-
-    /// Lower bound of normal reference range
-    pub reference_min: Option<f64>,
-
-    /// Upper bound of normal reference range
-    pub reference_max: Option<f64>,
-
-    #[sea_orm(column_type = "Text", nullable)]
-    pub description: Option<String>,
-}
-
-#[derive(Copy, Clone, Debug, EnumIter, DeriveRelation)]
-pub enum Relation {
-    #[sea_orm(has_many = "super::biomarker_entry::Entity")]
-    Entries,
-}
-
-impl Related<super::biomarker_entry::Entity> for Entity {
-    fn to() -> RelationDef {
-        Relation::Entries.def()
-    }
-}
-
-impl ActiveModelBehavior for ActiveModel {}

backend/src/models/bio/mod.rs

@@ -1,7 +1,11 @@
-//! Biomarker entities for health data tracking.
+//! Biomarker-related entities.
 
+pub mod biomarker;
+pub mod biomarker_category;
 pub mod biomarker_entry;
-pub mod biomarker_type;
+pub mod biomarker_reference_rule;
 
+pub use biomarker::Entity as Biomarker;
+pub use biomarker_category::Entity as BiomarkerCategory;
 pub use biomarker_entry::Entity as BiomarkerEntry;
-pub use biomarker_type::Entity as BiomarkerType;
+pub use biomarker_reference_rule::Entity as BiomarkerReferenceRule;

backend/src/models/mod.rs

@@ -3,5 +3,5 @@
 pub mod bio;
 pub mod user;
 
-pub use bio::{BiomarkerEntry, BiomarkerType};
-pub use user::{Session, User};
+pub use bio::{Biomarker, BiomarkerCategory, BiomarkerEntry};
+pub use user::{Role, Session, User};

backend/src/seed.rs

@@ -0,0 +1,452 @@
+//! Seed data loading and syncing.
+
+use sea_orm::{ActiveModelTrait, ColumnTrait, DatabaseConnection, EntityTrait, QueryFilter, Set};
+use serde::Deserialize;
+use serde_yaml::Value;
+use std::fs;
+use std::path::Path;
+
+use crate::models::bio::{biomarker, biomarker_category, biomarker_reference_rule};
+use crate::models::user::role;
+
+// ============================================================================
+// Seed Data Structures
+// ============================================================================
+
+#[derive(Debug, Deserialize)]
+pub struct SeedData {
+    pub roles: Vec<RoleSeed>,
+    pub biomarker_categories: Vec<BiomarkerCategorySeed>,
+}
+
+#[derive(Debug, Deserialize)]
+pub struct BiomarkerSeedData {
+    pub biomarkers: Vec<BiomarkerSeed>,
+}
+
+#[derive(Debug, Deserialize)]
+pub struct RoleSeed {
+    pub name: String,
+    pub description: Option<String>,
+}
+
+#[derive(Debug, Deserialize)]
+pub struct BiomarkerCategorySeed {
+    pub name: String,
+    pub description: Option<String>,
+}
+
+#[derive(Debug, Deserialize)]
+pub struct BiomarkerSeed {
+    pub name: String,
+    pub test_category: String,
+    pub category: String,
+    pub unit: String,
+    pub methodology: Option<String>,
+    pub description: Option<String>,
+    #[serde(default)]
+    pub reference: Option<Value>,
+    #[serde(default)]
+    pub scale: Option<Value>,
+    #[serde(default)]
+    pub scale_risk: Option<Value>,
+    #[serde(default)]
+    pub scale_diabetic_control: Option<Value>,
+}
+
+impl SeedData {
+    pub fn load<P: AsRef<Path>>(path: P) -> anyhow::Result<Self> {
+        let content = fs::read_to_string(path)?;
+        let data: SeedData = serde_yaml::from_str(&content)?;
+        Ok(data)
+    }
+}
+
+impl BiomarkerSeedData {
+    pub fn load<P: AsRef<Path>>(path: P) -> anyhow::Result<Self> {
+        let content = fs::read_to_string(path)?;
+        let data: BiomarkerSeedData = serde_yaml::from_str(&content)?;
+        Ok(data)
+    }
+}
+
+// ============================================================================
+// Reference Rule Builder
+// ============================================================================
+
+#[derive(Debug, Default)]
+struct RuleBuilder {
+    rules: Vec<RuleData>,
+}
+
+#[derive(Debug, Clone)]
+struct RuleData {
+    rule_type: String,
+    sex: String,
+    age_min: Option<i32>,
+    age_max: Option<i32>,
+    time_of_day: Option<String>,
+    life_stage: Option<String>,
+    value_min: Option<f64>,
+    value_max: Option<f64>,
+    expected_value: Option<String>,
+    label: String,
+    severity: i32,
+    sort_order: i32,
+}
+
+impl RuleBuilder {
+    fn new() -> Self {
+        Self { rules: Vec::new() }
+    }
+
+    /// Parse a reference/scale value and generate rules
+    fn parse_reference(&mut self, value: &Value, sex: &str, life_stage: Option<&str>) {
+        match value {
+            Value::Mapping(map) => {
+                // Check for special keys
+                if let Some(min) = map.get(&Value::String("min".into())) {
+                    // Simple {min, max} structure
+                    let max = map.get(&Value::String("max".into()));
+                    self.add_range_rule(sex, life_stage, 
+                        min.as_f64(), 
+                        max.and_then(|v| v.as_f64()),
+                        "Normal", 0);
+                    return;
+                }
+                
+                if let Some(max_only) = map.get(&Value::String("max".into())) {
+                    if map.len() == 1 {
+                        // Only max specified
+                        self.add_range_rule(sex, life_stage, None, max_only.as_f64(), "Normal", 0);
+                        return;
+                    }
+                }
+
+                if let Some(expected) = map.get(&Value::String("expected".into())) {
+                    // Expected value for qualitative tests
+                    self.add_expected_rule(sex, expected.as_str().unwrap_or(""), "Normal", 0);
+                    return;
+                }
+
+                if let Some(by_age) = map.get(&Value::String("by_age".into())) {
+                    // Age-based reference
+                    self.parse_by_age(by_age, sex, life_stage);
+                    return;
+                }
+
+                if let Some(by_time) = map.get(&Value::String("by_time".into())) {
+                    // Time-based reference (diurnal variation)
+                    self.parse_by_time(by_time, sex);
+                    return;
+                }
+
+                // Check for sex-specific keys
+                for (key, val) in map {
+                    if let Some(key_str) = key.as_str() {
+                        match key_str {
+                            "male" => self.parse_reference(val, "male", life_stage),
+                            "female" => self.parse_reference(val, "female", life_stage),
+                            "prepubertal" => self.parse_reference(val, sex, Some("prepubertal")),
+                            "adult" => self.parse_reference(val, sex, Some("adult")),
+                            "menstrual" => self.parse_menstrual(val, sex),
+                            "postmenopausal" => self.parse_reference(val, sex, Some("postmenopausal")),
+                            "pregnancy" => self.parse_reference(val, sex, Some("pregnancy")),
+                            "post_acth" => self.parse_reference(val, sex, Some("post_acth")),
+                            "no_hrt" => self.parse_reference(val, sex, Some("postmenopausal_no_hrt")),
+                            "on_hrt" => self.parse_reference(val, sex, Some("postmenopausal_on_hrt")),
+                            _ => {}
+                        }
+                    }
+                }
+            }
+            _ => {}
+        }
+    }
+
+    fn parse_menstrual(&mut self, value: &Value, sex: &str) {
+        if let Value::Mapping(map) = value {
+            for (key, val) in map {
+                if let Some(key_str) = key.as_str() {
+                    match key_str {
+                        "follicular" => self.parse_reference(val, sex, Some("follicular")),
+                        "midcycle" => self.parse_reference(val, sex, Some("midcycle")),
+                        "luteal" => self.parse_reference(val, sex, Some("luteal")),
+                        _ => {}
+                    }
+                }
+            }
+        }
+    }
+
+    fn parse_by_age(&mut self, value: &Value, sex: &str, life_stage: Option<&str>) {
+        if let Value::Sequence(arr) = value {
+            for item in arr {
+                if let Value::Mapping(map) = item {
+                    let age_min = map.get(&Value::String("age_min".into()))
+                        .and_then(|v| v.as_i64()).map(|v| v as i32);
+                    let age_max = map.get(&Value::String("age_max".into()))
+                        .and_then(|v| v.as_i64()).map(|v| v as i32);
+                    let val_min = map.get(&Value::String("min".into())).and_then(|v| v.as_f64());
+                    let val_max = map.get(&Value::String("max".into())).and_then(|v| v.as_f64());
+
+                    self.rules.push(RuleData {
+                        rule_type: "range".into(),
+                        sex: sex.into(),
+                        age_min,
+                        age_max,
+                        time_of_day: None,
+                        life_stage: life_stage.map(String::from),
+                        value_min: val_min,
+                        value_max: val_max,
+                        expected_value: None,
+                        label: "Normal".into(),
+                        severity: 0,
+                        sort_order: self.rules.len() as i32,
+                    });
+                }
+            }
+        }
+    }
+
+    fn parse_by_time(&mut self, value: &Value, sex: &str) {
+        if let Value::Mapping(map) = value {
+            for (key, val) in map {
+                if let Some(time_str) = key.as_str() {
+                    if let Value::Mapping(range_map) = val {
+                        let val_min = range_map.get(&Value::String("min".into())).and_then(|v| v.as_f64());
+                        let val_max = range_map.get(&Value::String("max".into())).and_then(|v| v.as_f64());
+                        
+                        self.rules.push(RuleData {
+                            rule_type: "range".into(),
+                            sex: sex.into(),
+                            age_min: None,
+                            age_max: None,
+                            time_of_day: Some(time_str.into()),
+                            life_stage: None,
+                            value_min: val_min,
+                            value_max: val_max,
+                            expected_value: None,
+                            label: "Normal".into(),
+                            severity: 0,
+                            sort_order: self.rules.len() as i32,
+                        });
+                    }
+                }
+            }
+        }
+    }
+
+    fn parse_scale(&mut self, value: &Value, sex: &str) {
+        if let Value::Sequence(arr) = value {
+            for (idx, item) in arr.iter().enumerate() {
+                if let Value::Mapping(map) = item {
+                    let val_min = map.get(&Value::String("min".into())).and_then(|v| v.as_f64());
+                    let val_max = map.get(&Value::String("max".into())).and_then(|v| v.as_f64());
+                    let label = map.get(&Value::String("label".into()))
+                        .and_then(|v| v.as_str()).unwrap_or("Unknown");
+
+                    // Determine severity based on label keywords
+                    let severity = Self::infer_severity(label);
+
+                    self.rules.push(RuleData {
+                        rule_type: "scale".into(),
+                        sex: sex.into(),
+                        age_min: None,
+                        age_max: None,
+                        time_of_day: None,
+                        life_stage: None,
+                        value_min: val_min,
+                        value_max: val_max,
+                        expected_value: None,
+                        label: label.into(),
+                        severity,
+                        sort_order: idx as i32,
+                    });
+                }
+            }
+        }
+    }
+
+    fn add_range_rule(&mut self, sex: &str, life_stage: Option<&str>, 
+                       val_min: Option<f64>, val_max: Option<f64>, label: &str, severity: i32) {
+        self.rules.push(RuleData {
+            rule_type: "range".into(),
+            sex: sex.into(),
+            age_min: None,
+            age_max: None,
+            time_of_day: None,
+            life_stage: life_stage.map(String::from),
+            value_min: val_min,
+            value_max: val_max,
+            expected_value: None,
+            label: label.into(),
+            severity,
+            sort_order: self.rules.len() as i32,
+        });
+    }
+
+    fn add_expected_rule(&mut self, sex: &str, expected: &str, label: &str, severity: i32) {
+        self.rules.push(RuleData {
+            rule_type: "expected".into(),
+            sex: sex.into(),
+            age_min: None,
+            age_max: None,
+            time_of_day: None,
+            life_stage: None,
+            value_min: None,
+            value_max: None,
+            expected_value: Some(expected.into()),
+            label: label.into(),
+            severity,
+            sort_order: self.rules.len() as i32,
+        });
+    }
+
+    fn infer_severity(label: &str) -> i32 {
+        let lower = label.to_lowercase();
+        if lower.contains("normal") || lower.contains("optimal") || lower.contains("good") 
+            || lower.contains("negative") || lower.contains("sufficiency") || lower.contains("desirable") {
+            0
+        } else if lower.contains("mild") || lower.contains("borderline") || lower.contains("low risk")
+            || lower.contains("insufficiency") || lower.contains("prediabetes") || lower.contains("fair") {
+            1
+        } else if lower.contains("moderate") || lower.contains("average risk") || lower.contains("elevated") {
+            2
+        } else if lower.contains("severe") || lower.contains("high risk") || lower.contains("high") {
+            3
+        } else if lower.contains("critical") || lower.contains("failure") || lower.contains("diabetes")
+            || lower.contains("very high") || lower.contains("toxicity") || lower.contains("poor") {
+            4
+        } else if lower.contains("positive") {
+            2  // Positive results for autoimmune tests are concerning
+        } else {
+            1  // Default to mild concern for unknown labels
+        }
+    }
+}
+
+// ============================================================================
+// Sync Functions
+// ============================================================================
+
+/// Sync seed data to the database (upsert by name).
+pub async fn sync_seed_data(db: &DatabaseConnection, seed: &SeedData) -> anyhow::Result<()> {
+    // Sync roles
+    for role_seed in &seed.roles {
+        let existing = role::Entity::find()
+            .filter(role::Column::Name.eq(&role_seed.name))
+            .one(db)
+            .await?;
+
+        if existing.is_none() {
+            let new_role = role::ActiveModel {
+                name: Set(role_seed.name.clone()),
+                description: Set(role_seed.description.clone()),
+                ..Default::default()
+            };
+            new_role.insert(db).await?;
+            tracing::info!("Inserted role: {}", role_seed.name);
+        }
+    }
+
+    // Sync biomarker categories
+    for cat_seed in &seed.biomarker_categories {
+        let existing = biomarker_category::Entity::find()
+            .filter(biomarker_category::Column::Name.eq(&cat_seed.name))
+            .one(db)
+            .await?;
+
+        if existing.is_none() {
+            let new_cat = biomarker_category::ActiveModel {
+                name: Set(cat_seed.name.clone()),
+                description: Set(cat_seed.description.clone()),
+                ..Default::default()
+            };
+            new_cat.insert(db).await?;
+            tracing::info!("Inserted category: {}", cat_seed.name);
+        }
+    }
+
+    Ok(())
+}
+
+/// Sync biomarker seed data from seed_biomarkers.yaml
+pub async fn sync_biomarker_data(db: &DatabaseConnection, seed: &BiomarkerSeedData) -> anyhow::Result<()> {
+    for bm_seed in &seed.biomarkers {
+        let existing = biomarker::Entity::find()
+            .filter(biomarker::Column::Name.eq(&bm_seed.name))
+            .one(db)
+            .await?;
+
+        if existing.is_some() {
+            continue;
+        }
+
+        // Look up category
+        let category = biomarker_category::Entity::find()
+            .filter(biomarker_category::Column::Name.eq(&bm_seed.category))
+            .one(db)
+            .await?
+            .ok_or_else(|| anyhow::anyhow!("Category not found: {}", bm_seed.category))?;
+
+        // Insert biomarker
+        let new_bm = biomarker::ActiveModel {
+            category_id: Set(category.id),
+            name: Set(bm_seed.name.clone()),
+            test_category: Set(bm_seed.test_category.clone()),
+            unit: Set(bm_seed.unit.clone()),
+            methodology: Set(bm_seed.methodology.clone()),
+            description: Set(bm_seed.description.clone()),
+            ..Default::default()
+        };
+        let inserted = new_bm.insert(db).await?;
+        tracing::info!("Inserted biomarker: {}", bm_seed.name);
+
+        // Parse and insert reference rules
+        let mut builder = RuleBuilder::new();
+
+        if let Some(ref reference) = bm_seed.reference {
+            builder.parse_reference(reference, "any", None);
+        }
+
+        if let Some(ref scale) = bm_seed.scale {
+            builder.parse_scale(scale, "any");
+        }
+
+        if let Some(ref scale_risk) = bm_seed.scale_risk {
+            // For sex-specific scale_risk like Troponin
+            if let Value::Mapping(map) = scale_risk {
+                if let Some(male_scale) = map.get(&Value::String("male".into())) {
+                    builder.parse_scale(male_scale, "male");
+                }
+                if let Some(female_scale) = map.get(&Value::String("female".into())) {
+                    builder.parse_scale(female_scale, "female");
+                }
+            }
+        }
+
+        // Insert all generated rules
+        for rule in builder.rules {
+            let new_rule = biomarker_reference_rule::ActiveModel {
+                biomarker_id: Set(inserted.id),
+                rule_type: Set(rule.rule_type),
+                sex: Set(rule.sex),
+                age_min: Set(rule.age_min),
+                age_max: Set(rule.age_max),
+                time_of_day: Set(rule.time_of_day),
+                life_stage: Set(rule.life_stage),
+                value_min: Set(rule.value_min),
+                value_max: Set(rule.value_max),
+                expected_value: Set(rule.expected_value),
+                label: Set(rule.label),
+                severity: Set(rule.severity),
+                sort_order: Set(rule.sort_order),
+                ..Default::default()
+            };
+            new_rule.insert(db).await?;
+        }
+    }
+
+    Ok(())
+}