# Biomarker Seed Data for zhealth
# Normalized schema with structured reference ranges
#
# Reference Range Structure Types:
# 1. Simple universal: reference: { min, max }
# 2. Gender-specific: reference: { male: {min, max}, female: {min, max} }
# 3. Age-based: reference: { by_age: [ {age_min, age_max, min, max} ] }
# 4. Female phases: reference: { male: {...}, female: { menstrual: {...}, postmenopausal: {...} } }
# 5. Scale/interpretation: scale: [ {min, max, label} ]
# 6. Time-based: reference: { by_time: { "08:00": {...}, "16:00": {...} } }

biomarkers:
  # ============================================================================
  # TOXIC ELEMENTS
  # ============================================================================
  - name: "ARSENIC"
    test_category: TOXIC ELEMENTS
    category: toxicology
    unit: "µg/L"
    methodology: "Inductively Coupled Plasma Mass Spectrometry"
    reference:
      min: 0.0
      max: 5.0

  - name: "CADMIUM"
    test_category: TOXIC ELEMENTS
    category: toxicology
    unit: "µg/L"
    methodology: "ICP - MASS SPECTROMETRY"
    reference:
      min: 0.0
      max: 1.5

  - name: "MERCURY"
    test_category: TOXIC ELEMENTS
    category: toxicology
    unit: "µg/L"
    methodology: "ICP - MASS SPECTROMETRY"
    reference:
      min: 0.0
      max: 5.0

  - name: "LEAD"
    test_category: TOXIC ELEMENTS
    category: toxicology
    unit: "µg/L"
    methodology: "ICP - MASS SPECTROMETRY"
    reference:
      min: 0.0
      max: 150.0

  - name: "CHROMIUM"
    test_category: TOXIC ELEMENTS
    category: toxicology
    unit: "µg/L"
    methodology: "ICP - MASS SPECTROMETRY"
    reference:
      min: 0.0
      max: 30.0

  - name: "BARIUM"
    test_category: TOXIC ELEMENTS
    category: toxicology
    unit: "µg/L"
    methodology: "ICP - MASS SPECTROMETRY"
    reference:
      min: 0.0
      max: 30.0

  - name: "COBALT"
    test_category: TOXIC ELEMENTS
    category: toxicology
    unit: "µg/L"
    methodology: "ICP - MASS SPECTROMETRY"
    reference:
      min: 0.1
      max: 1.5

  - name: "CAESIUM"
    test_category: TOXIC ELEMENTS
    category: toxicology
    unit: "µg/L"
    methodology: "ICP - MASS SPECTROMETRY"
    reference:
      min: 0.0
      max: 5.0

  - name: "THALLIUM"
    test_category: TOXIC ELEMENTS
    category: toxicology
    unit: "µg/L"
    methodology: "ICP - MASS SPECTROMETRY"
    reference:
      min: 0.0
      max: 1.0

  - name: "URANIUM"
    test_category: TOXIC ELEMENTS
    category: toxicology
    unit: "µg/L"
    methodology: "ICP - MASS SPECTROMETRY"
    reference:
      min: 0.0
      max: 1.0

  - name: "STRONTIUM"
    test_category: TOXIC ELEMENTS
    category: toxicology
    unit: "µg/L"
    methodology: "ICP - MASS SPECTROMETRY"
    reference:
      min: 8.0
      max: 38.0

  - name: "ANTIMONY"
    test_category: TOXIC ELEMENTS
    category: toxicology
    unit: "µg/L"
    methodology: "ICP - MASS SPECTROMETRY"
    reference:
      min: 0.1
      max: 18.0

  - name: "TIN"
    test_category: TOXIC ELEMENTS
    category: toxicology
    unit: "µg/L"
    methodology: "ICP - MASS SPECTROMETRY"
    reference:
      min: 0.0
      max: 2.0

  - name: "MOLYBDENUM"
    test_category: TOXIC ELEMENTS
    category: toxicology
    unit: "µg/L"
    methodology: "ICP - MASS SPECTROMETRY"
    reference:
      min: 0.7
      max: 4.0

  - name: "SILVER"
    test_category: TOXIC ELEMENTS
    category: toxicology
    unit: "µg/L"
    methodology: "ICP - MASS SPECTROMETRY"
    reference:
      min: 0.0
      max: 4.0

  - name: "VANADIUM"
    test_category: TOXIC ELEMENTS
    category: toxicology
    unit: "µg/L"
    methodology: "ICP - MASS SPECTROMETRY"
    reference:
      min: 0.0
      max: 0.8

  - name: "BERYLLIUM"
    test_category: TOXIC ELEMENTS
    category: toxicology
    unit: "µg/L"
    methodology: "ICP - MASS SPECTROMETRY"
    reference:
      min: 0.0
      max: 0.1

  - name: "BISMUTH"
    test_category: TOXIC ELEMENTS
    category: toxicology
    unit: "µg/L"
    methodology: "ICP - MASS SPECTROMETRY"
    reference:
      min: 0.1
      max: 0.8

  - name: "SELENIUM"
    test_category: TOXIC ELEMENTS
    category: toxicology
    unit: "µg/L"
    methodology: "ICP - MASS SPECTROMETRY"
    reference:
      min: 60.0
      max: 340.0

  - name: "ALUMINIUM"
    test_category: TOXIC ELEMENTS
    category: toxicology
    unit: "µg/L"
    methodology: "ICP - MASS SPECTROMETRY"
    reference:
      min: 0.0
      max: 30.0

  - name: "NICKEL"
    test_category: TOXIC ELEMENTS
    category: toxicology
    unit: "µg/L"
    methodology: "ICP - MASS SPECTROMETRY"
    reference:
      min: 0.0
      max: 15.0

  - name: "MANGANESE"
    test_category: TOXIC ELEMENTS
    category: toxicology
    unit: "µg/L"
    methodology: "ICP - MASS SPECTROMETRY"
    reference:
      min: 7.1
      max: 20.0

  # ============================================================================
  # DIABETES / METABOLIC - Scale-based interpretations
  # ============================================================================
  - name: "HbA1c"
    test_category: DIABETES
    category: metabolic
    unit: "%"
    methodology: "High Performance Liquid Chromatography"
    scale:
      - { max: 5.7, label: "Normal" }
      - { min: 5.7, max: 6.4, label: "Prediabetes" }
      - { min: 6.5, label: "Diabetes" }
    scale_diabetic_control:
      - { max: 6.5, label: "Good Control" }
      - { min: 6.5, max: 7.0, label: "Fair Control" }
      - { min: 7.0, max: 8.0, label: "Unsatisfactory Control" }
      - { min: 8.0, label: "Poor Control" }

  - name: "AVERAGE BLOOD GLUCOSE (ABG)"
    test_category: DIABETES
    category: metabolic
    unit: "mg/dL"
    methodology: "Calculated from HbA1c values"
    scale:
      - { min: 90, max: 120, label: "Good Control" }
      - { min: 121, max: 150, label: "Fair Control" }
      - { min: 151, max: 180, label: "Unsatisfactory Control" }
      - { min: 181, label: "Poor Control" }

  - name: "FASTING BLOOD SUGAR (GLUCOSE)"
    test_category: DIABETES
    category: metabolic
    unit: "mg/dL"
    methodology: "Glucose Oxidase Peroxidase Method"
    scale:
      - { min: 70, max: 100, label: "Normal" }
      - { min: 100, max: 125, label: "Prediabetes" }
      - { min: 126, label: "Diabetes" }

  - name: "INSULIN FASTING"
    test_category: DIABETES
    category: metabolic
    unit: "µU/mL"
    methodology: "Chemiluminescent Immunoassay"
    reference:
      min: 1.9
      max: 23.0

  - name: "FRUCTOSAMINE"
    test_category: DIABETES
    category: metabolic
    unit: "µmol/L"
    methodology: "Nitroblue Tetrazolium Assay"
    reference:
      max: 286.0

  - name: "BLOOD KETONE (D3HB)"
    test_category: DIABETES
    category: metabolic
    unit: "mg/dL"
    methodology: "Enzymatic Kinetic Assay"
    reference:
      min: 0.21
      max: 2.81

  # ============================================================================
  # INFLAMMATION
  # ============================================================================
  - name: "ERYTHROCYTE SEDIMENTATION RATE (ESR)"
    test_category: INFLAMMATION
    category: inflammation
    unit: "mm/hr"
    methodology: "Modified Westergren Method"
    reference:
      male:
        min: 0.0
        max: 15.0
      female:
        min: 0.0
        max: 20.0

  - name: "ANTI CCP (ACCP)"
    test_category: ARTHRITIS
    category: inflammation
    unit: "U/mL"
    methodology: "Chemiluminescent Microparticle Immunoassay"
    scale:
      - { max: 5.0, label: "Negative" }
      - { min: 5.0, label: "Positive" }

  - name: "ANTI NUCLEAR ANTIBODIES (ANA)"
    test_category: ARTHRITIS
    category: inflammation
    unit: "AU/mL"
    methodology: "C.M.I.A"
    scale:
      - { max: 20.0, label: "Negative" }
      - { min: 20.0, label: "Positive" }

  # ============================================================================
  # HEMOGRAM / COMPLETE BLOOD COUNT
  # ============================================================================
  - name: "HEMOGLOBIN"
    test_category: HEMOGRAM
    category: blood
    unit: "g/dL"
    methodology: "Sodium Lauryl Sulfate Hemoglobin Method"
    reference:
      male:
        min: 13.0
        max: 17.0
      female:
        min: 12.0
        max: 15.0

  - name: "HEMATOCRIT (PCV)"
    test_category: HEMOGRAM
    category: blood
    unit: "%"
    methodology: "Cumulative Pulse Height Detection"
    reference:
      male:
        min: 40.0
        max: 50.0
      female:
        min: 36.0
        max: 44.0

  - name: "TOTAL RBC"
    test_category: HEMOGRAM
    category: blood
    unit: "10^6/µL"
    methodology: "Hydrodynamic Focusing and Electrical Impedance"
    reference:
      male:
        min: 4.5
        max: 5.5
      female:
        min: 4.0
        max: 5.0

  - name: "MEAN CORPUSCULAR VOLUME (MCV)"
    test_category: HEMOGRAM
    category: blood
    unit: "fL"
    methodology: "Calculated from RBC and Hematocrit"
    reference:
      min: 83.0
      max: 101.0

  - name: "MEAN CORPUSCULAR HEMOGLOBIN (MCH)"
    test_category: HEMOGRAM
    category: blood
    unit: "pg"
    methodology: "Calculated from Hemoglobin and RBC"
    reference:
      min: 27.0
      max: 32.0

  - name: "MEAN CORP. HEMO. CONC (MCHC)"
    test_category: HEMOGRAM
    category: blood
    unit: "g/dL"
    methodology: "Calculated from Hemoglobin and Hematocrit"
    reference:
      min: 31.5
      max: 34.5

  - name: "RED CELL DISTRIBUTION WIDTH - SD (RDW-SD)"
    test_category: HEMOGRAM
    category: blood
    unit: "fL"
    methodology: "Calculated from Red Cell Volume Distribution"
    reference:
      min: 39.0
      max: 46.0

  - name: "RED CELL DISTRIBUTION WIDTH (RDW-CV)"
    test_category: HEMOGRAM
    category: blood
    unit: "%"
    methodology: "Calculated from Red Cell Volume Distribution"
    reference:
      min: 11.6
      max: 14.0

  - name: "TOTAL LEUCOCYTE COUNT (WBC)"
    test_category: HEMOGRAM
    category: blood
    unit: "10^3/µL"
    methodology: "Hydrodynamic Focusing and Flow Cytometry"
    reference:
      min: 4.0
      max: 10.0

  - name: "NEUTROPHILS PERCENTAGE"
    test_category: HEMOGRAM
    category: blood
    unit: "%"
    methodology: "Flow Cytometry"
    reference:
      min: 40.0
      max: 80.0

  - name: "LYMPHOCYTES PERCENTAGE"
    test_category: HEMOGRAM
    category: blood
    unit: "%"
    methodology: "Flow Cytometry"
    reference:
      min: 20.0
      max: 40.0

  - name: "MONOCYTES PERCENTAGE"
    test_category: HEMOGRAM
    category: blood
    unit: "%"
    methodology: "Flow Cytometry"
    reference:
      min: 2.0
      max: 10.0

  - name: "EOSINOPHILS PERCENTAGE"
    test_category: HEMOGRAM
    category: blood
    unit: "%"
    methodology: "Flow Cytometry"
    reference:
      min: 1.0
      max: 6.0

  - name: "BASOPHILS PERCENTAGE"
    test_category: HEMOGRAM
    category: blood
    unit: "%"
    methodology: "Flow Cytometry"
    reference:
      min: 0.0
      max: 2.0

  - name: "IMMATURE GRANULOCYTE PERCENTAGE (IG%)"
    test_category: HEMOGRAM
    category: blood
    unit: "%"
    methodology: "Flow Cytometry"
    reference:
      min: 0.0
      max: 0.5

  - name: "NUCLEATED RED BLOOD CELLS %"
    test_category: HEMOGRAM
    category: blood
    unit: "%"
    methodology: "Flow Cytometry"
    reference:
      min: 0.0
      max: 5.0

  - name: "NEUTROPHILS ABSOLUTE COUNT"
    test_category: HEMOGRAM
    category: blood
    unit: "10^3/µL"
    methodology: "Calculated from Total WBC and Differential Count"
    reference:
      min: 2.0
      max: 7.0

  - name: "LYMPHOCYTES ABSOLUTE COUNT"
    test_category: HEMOGRAM
    category: blood
    unit: "10^3/µL"
    methodology: "Calculated from Total WBC and Differential Count"
    reference:
      min: 1.0
      max: 3.0

  - name: "MONOCYTES - ABSOLUTE COUNT"
    test_category: HEMOGRAM
    category: blood
    unit: "10^3/µL"
    methodology: "Calculated from Total WBC and Differential Count"
    reference:
      min: 0.2
      max: 1.0

  - name: "BASOPHILS ABSOLUTE COUNT"
    test_category: HEMOGRAM
    category: blood
    unit: "10^3/µL"
    methodology: "Calculated from Total WBC and Differential Count"
    reference:
      min: 0.02
      max: 0.1

  - name: "EOSINOPHILS ABSOLUTE COUNT"
    test_category: HEMOGRAM
    category: blood
    unit: "10^3/µL"
    methodology: "Calculated from Total WBC and Differential Count"
    reference:
      min: 0.02
      max: 0.5

  - name: "IMMATURE GRANULOCYTES (IG)"
    test_category: HEMOGRAM
    category: blood
    unit: "10^3/µL"
    methodology: "Calculated from Total WBC and Differential Count"
    reference:
      min: 0.0
      max: 0.3

  - name: "NUCLEATED RED BLOOD CELLS"
    test_category: HEMOGRAM
    category: blood
    unit: "10^3/µL"
    methodology: "Calculated from Total WBC and Differential Count"
    reference:
      min: 0.0
      max: 0.5

  - name: "PLATELET COUNT"
    test_category: HEMOGRAM
    category: blood
    unit: "10^3/µL"
    methodology: "Hydrodynamic Focusing and Electrical Impedance"
    reference:
      min: 150.0
      max: 410.0

  - name: "MEAN PLATELET VOLUME (MPV)"
    test_category: HEMOGRAM
    category: blood
    unit: "fL"
    methodology: "Calculated from Platelet Size Distribution"
    reference:
      min: 6.5
      max: 12.0

  - name: "PLATELET DISTRIBUTION WIDTH (PDW)"
    test_category: HEMOGRAM
    category: blood
    unit: "fL"
    methodology: "Calculated from Platelet Size Distribution"
    reference:
      min: 9.6
      max: 15.2

  - name: "PLATELET TO LARGE CELL RATIO (PLCR)"
    test_category: HEMOGRAM
    category: blood
    unit: "%"
    methodology: "Calculated from Platelet Size Distribution"
    reference:
      min: 19.7
      max: 42.4

  - name: "PLATELETCRIT (PCT)"
    test_category: HEMOGRAM
    category: blood
    unit: "%"
    methodology: "Calculated from Platelet Count and Volume"
    reference:
      min: 0.19
      max: 0.39

  # ============================================================================
  # VITAMINS - Age-based references
  # ============================================================================
  - name: "VITAMIN A"
    test_category: VITAMIN
    category: vitamins
    unit: "ng/mL"
    methodology: "Liquid Chromatography Tandem Mass Spectrometry"
    reference:
      by_age:
        - { age_min: 1, age_max: 6, min: 200, max: 400 }
        - { age_min: 7, age_max: 12, min: 260, max: 490 }
        - { age_min: 13, age_max: 19, min: 260, max: 720 }
        - { age_min: 18, min: 300, max: 800 }

  - name: "VITAMIN E"
    test_category: VITAMIN
    category: vitamins
    unit: "ng/mL"
    methodology: "Liquid Chromatography Tandem Mass Spectrometry"
    reference:
      by_age:
        - { age_max: 0.083, min: 1000, max: 3500 }  # < 1 month
        - { age_min: 0.083, age_max: 0.42, min: 2000, max: 6000 }  # 2-5 months
        - { age_min: 0.5, age_max: 1, min: 3500, max: 8000 }  # 6M - 1 year
        - { age_min: 2, age_max: 12, min: 5500, max: 9000 }
        - { age_min: 13, min: 5500, max: 18000 }

  - name: "VITAMIN K"
    test_category: VITAMIN
    category: vitamins
    unit: "ng/mL"
    methodology: "Liquid Chromatography Tandem Mass Spectrometry"
    reference:
      min: 0.13
      max: 1.19

  - name: "VITAMIN B1/THIAMIN"
    test_category: VITAMIN
    category: vitamins
    unit: "ng/mL"
    methodology: "Liquid Chromatography Tandem Mass Spectrometry"
    reference:
      min: 0.5
      max: 4.0

  - name: "VITAMIN B2/RIBOFLAVIN"
    test_category: VITAMIN
    category: vitamins
    unit: "ng/mL"
    methodology: "Liquid Chromatography Tandem Mass Spectrometry"
    reference:
      min: 1.6
      max: 68.2

  - name: "VITAMIN B3/NICOTINIC ACID"
    test_category: VITAMIN
    category: vitamins
    unit: "ng/mL"
    methodology: "Liquid Chromatography Tandem Mass Spectrometry"
    reference:
      max: 5.0

  - name: "VITAMIN B5/PANTOTHENIC"
    test_category: VITAMIN
    category: vitamins
    unit: "ng/mL"
    methodology: "Liquid Chromatography Tandem Mass Spectrometry"
    reference:
      min: 11.0
      max: 150.0

  - name: "VITAMIN B6/P5P"
    test_category: VITAMIN
    category: vitamins
    unit: "ng/mL"
    methodology: "Liquid Chromatography Tandem Mass Spectrometry"
    reference:
      min: 5.0
      max: 50.0

  - name: "VITAMIN B7/BIOTIN"
    test_category: VITAMIN
    category: vitamins
    unit: "ng/mL"
    methodology: "Liquid Chromatography Tandem Mass Spectrometry"
    reference:
      min: 0.2
      max: 3.0

  - name: "VITAMIN B9/FOLIC ACID"
    test_category: VITAMIN
    category: vitamins
    unit: "ng/mL"
    methodology: "Liquid Chromatography Tandem Mass Spectrometry"
    reference:
      min: 0.2
      max: 20.0

  - name: "VITAMIN B-12"
    test_category: VITAMIN
    category: vitamins
    unit: "pg/mL"
    methodology: "C.M.I.A"
    reference:
      min: 187.0
      max: 883.0

  - name: "VITAMIN D TOTAL"
    test_category: VITAMIN
    category: vitamins
    unit: "ng/mL"
    methodology: "Liquid Chromatography Tandem Mass Spectrometry"
    scale:
      - { max: 20, label: "Deficiency" }
      - { min: 20, max: 30, label: "Insufficiency" }
      - { min: 30, max: 100, label: "Sufficiency" }
      - { min: 100, label: "Toxicity" }

  - name: "VITAMIN D2"
    test_category: VITAMIN
    category: vitamins
    unit: "ng/mL"
    methodology: "Liquid Chromatography Tandem Mass Spectrometry"

  - name: "VITAMIN D3"
    test_category: VITAMIN
    category: vitamins
    unit: "ng/mL"
    methodology: "Liquid Chromatography Tandem Mass Spectrometry"

  # ============================================================================
  # STEROID HORMONES - Complex gender/phase references
  # ============================================================================
  - name: "CORTISOL"
    test_category: STEROID
    category: hormones
    unit: "µg/dL"
    methodology: "Liquid Chromatography Tandem Mass Spectrometry"
    reference:
      by_time:
        "08:00":
          min: 5.0
          max: 23.0
        "16:00":
          min: 3.0
          max: 16.0

  - name: "CORTICOSTERONE"
    test_category: STEROID
    category: hormones
    unit: "ng/dL"
    methodology: "Liquid Chromatography Tandem Mass Spectrometry"
    reference:
      by_age:
        - { age_max: 18, min: 18, max: 1970 }
        - { age_min: 18, min: 53, max: 1560 }

  - name: "ANDROSTENEDIONE"
    test_category: STEROID
    category: hormones
    unit: "ng/dL"
    methodology: "Liquid Chromatography Tandem Mass Spectrometry"
    reference:
      prepubertal:
        max: 5
      adult:
        min: 75
        max: 205
      female:
        postmenopausal:
          min: 82
          max: 275

  - name: "ESTRADIOL"
    test_category: STEROID
    category: hormones
    unit: "pg/mL"
    methodology: "FULLY AUTOMATED CHEMILUMINESCENT MICROPARTICLE IMMUNOASSAY"
    reference:
      male:
        min: 11.0
        max: 44.0
      female:
        menstrual:
          follicular:
            min: 21.0
            max: 251.0
          midcycle:
            min: 38.0
            max: 649.0
          luteal:
            min: 21.0
            max: 312.0
        postmenopausal:
          no_hrt:
            min: 0.0
            max: 28.0
          on_hrt:
            min: 0.0
            max: 144.0

  - name: "TESTOSTERONE"
    test_category: STEROID
    category: hormones
    unit: "ng/dL"
    methodology: "Liquid Chromatography Tandem Mass Spectrometry"
    reference:
      male:
        by_age:
          - { age_min: 1, age_max: 5, min: 2, max: 25 }
          - { age_min: 6, age_max: 9, min: 3, max: 30 }
          - { age_min: 18, min: 260, max: 1000 }
      female:
        by_age:
          - { age_min: 1, age_max: 5, min: 2, max: 10 }
          - { age_min: 6, age_max: 9, min: 2, max: 20 }
          - { age_min: 18, min: 15, max: 70 }

  - name: "PROGESTERONE"
    test_category: STEROID
    category: hormones
    unit: "ng/mL"
    methodology: "Liquid Chromatography Tandem Mass Spectrometry"
    reference:
      male:
        by_age:
          - { age_min: 5, age_max: 9, max: 0.7 }
          - { age_min: 10, age_max: 13, max: 1.2 }
          - { age_min: 14, age_max: 17, max: 0.8 }
          - { age_min: 18, age_max: 29, max: 0.3 }
          - { age_min: 30, max: 0.2 }
      female:
        by_age:
          - { age_min: 5, age_max: 9, max: 0.6 }
          - { age_min: 10, age_max: 13, max: 10.2 }
          - { age_min: 14, age_max: 17, max: 11.9 }
        menstrual:
          follicular:
            max: 2.7
          luteal:
            max: 31.4
        postmenopausal:
          max: 0.2

  - name: "17-HYDROXYPROGESTERONE"
    test_category: STEROID
    category: hormones
    unit: "ng/dL"
    methodology: "Liquid Chromatography Tandem Mass Spectrometry"
    reference:
      male:
        prepubertal:
          min: 3
          max: 90
        adult:
          min: 27
          max: 199
      female:
        prepubertal:
          min: 3
          max: 90
        menstrual:
          follicular:
            min: 15
            max: 70
          luteal:
            min: 35
            max: 290
        postmenopausal:
          max: 70
        pregnancy:
          min: 200
          max: 1200
        post_acth:
          max: 320

  - name: "DEHYDROEPIANDROSTERONE (DHEA)"
    test_category: STEROID
    category: hormones
    unit: "ng/dL"
    methodology: "Liquid Chromatography Tandem Mass Spectrometry"
    reference:
      male:
        by_age:
          - { age_min: 6, age_max: 9, min: 13, max: 187 }
          - { age_min: 10, age_max: 11, min: 31, max: 205 }
          - { age_min: 12, age_max: 14, min: 83, max: 258 }
          - { age_min: 18, min: 180, max: 1250 }
      female:
        by_age:
          - { age_min: 6, age_max: 9, min: 18, max: 189 }
          - { age_min: 10, age_max: 11, min: 112, max: 224 }
          - { age_min: 12, age_max: 14, min: 93, max: 360 }
          - { age_min: 18, min: 130, max: 980 }

  - name: "DHEA - SULPHATE (DHEAS)"
    test_category: STEROID
    category: hormones
    unit: "µg/dL"
    methodology: "Liquid Chromatography Tandem Mass Spectrometry"
    reference:
      male:
        by_age:
          - { age_min: 6, age_max: 9, min: 2.5, max: 145 }
          - { age_min: 10, age_max: 11, min: 15, max: 115 }
          - { age_min: 12, age_max: 17, min: 20, max: 555 }
          - { age_min: 18, age_max: 30, min: 125, max: 619 }
          - { age_min: 31, age_max: 50, min: 5, max: 532 }
          - { age_min: 51, age_max: 60, min: 20, max: 413 }
          - { age_min: 61, age_max: 83, min: 10, max: 285 }
      female:
        by_age:
          - { age_min: 6, age_max: 9, min: 2.5, max: 140 }
          - { age_min: 10, age_max: 11, min: 15, max: 260 }
          - { age_min: 12, age_max: 17, min: 20, max: 535 }
          - { age_min: 18, age_max: 30, min: 45, max: 380 }
          - { age_min: 31, age_max: 50, min: 12, max: 379 }
        postmenopausal:
          min: 30
          max: 260

  - name: "DEOXYCORTISOL"
    test_category: STEROID
    category: hormones
    unit: "ng/dL"
    methodology: "Liquid Chromatography Tandem Mass Spectrometry"
    reference:
      min: 20
      max: 158

  - name: "ALPHA-1-ANTITRYPSIN (AAT)"
    test_category: PROTEIN
    category: metabolic
    unit: "mg/dL"
    methodology: "IMMUNOTURBIDIMETRY"
    reference:
      min: 90.0
      max: 200.0

  # ============================================================================
  # CARDIAC / CARDIOVASCULAR MARKERS
  # ============================================================================
  - name: "HOMOCYSTEINE"
    test_category: CARDIAC
    category: cardiac
    unit: "µmol/L"
    methodology: "Small Molecule Photometry Technology"
    scale:
      - { max: 15, label: "Normal" }
      - { min: 15, max: 30, label: "Mild Hyperhomocysteinemia" }
      - { min: 30, max: 100, label: "Moderate Hyperhomocysteinemia" }
      - { min: 100, label: "Severe Hyperhomocysteinemia" }

  - name: "TROPONIN I"
    test_category: CARDIAC
    category: cardiac
    unit: "pg/mL"
    methodology: "C.M.I.A"
    reference:
      male:
        max: 26.2
      female:
        max: 15.6
    scale_risk:
      male:
        - { max: 6, label: "Low risk of future heart attack" }
        - { min: 6, max: 12, label: "Moderate risk of future heart attack" }
        - { min: 12, label: "Elevated risk of future heart attack" }
      female:
        - { max: 4, label: "Low risk of future heart attack" }
        - { min: 4, max: 10, label: "Moderate risk of future heart attack" }
        - { min: 10, label: "Elevated risk of future heart attack" }

  - name: "HS-CRP"
    test_category: CARDIAC
    category: cardiac
    unit: "mg/L"
    methodology: "IMMUNOTURBIDIMETRY"
    scale:
      - { max: 1.0, label: "Low Risk" }
      - { min: 1.0, max: 3.0, label: "Average Risk" }
      - { min: 3.0, max: 10.0, label: "High Risk" }
      - { min: 10.0, label: "Non-Cardiac Inflammation" }

  - name: "LIPOPROTEIN (A) [Lp(a)]"
    test_category: CARDIAC
    category: cardiac
    unit: "mg/dL"
    methodology: "IMMUNOTURBIDIMETRY"
    reference:
      max: 30.0

  - name: "LP-PLA2"
    test_category: CARDIAC
    category: cardiac
    unit: "nmol/min/mL"
    methodology: "ENZYMATIC ASSAY"
    scale:
      - { max: 225, label: "Low Risk" }
      - { min: 225, label: "High Risk" }

  # ============================================================================
  # RENAL / KIDNEY MARKERS
  # ============================================================================
  - name: "CYSTATIN C"
    test_category: RENAL
    category: renal
    unit: "mg/L"
    methodology: "IMMUNOTURBIDIMETRY"
    reference:
      by_age:
        - { age_max: 60, max: 1.03 }
        - { age_min: 60, max: 1.50 }

  - name: "BLOOD UREA NITROGEN (BUN)"
    test_category: RENAL
    category: renal
    unit: "mg/dL"
    methodology: "KINETIC UV ASSAY"
    reference:
      min: 7.94
      max: 20.07

  - name: "UREA (CALCULATED)"
    test_category: RENAL
    category: renal
    unit: "mg/dL"
    methodology: "CALCULATED"
    reference:
      min: 17
      max: 43

  - name: "CREATININE - SERUM"
    test_category: RENAL
    category: renal
    unit: "mg/dL"
    methodology: "ENZYMATIC"
    reference:
      male:
        min: 0.72
        max: 1.18
      female:
        min: 0.55
        max: 1.02

  - name: "UREA / SR.CREATININE RATIO"
    test_category: RENAL
    category: renal
    unit: "Ratio"
    methodology: "CALCULATED"
    reference:
      max: 52

  - name: "BUN / SR.CREATININE RATIO"
    test_category: RENAL
    category: renal
    unit: "Ratio"
    methodology: "CALCULATED"
    reference:
      min: 9
      max: 23

  - name: "CALCIUM"
    test_category: RENAL
    category: renal
    unit: "mg/dL"
    methodology: "ARSENAZO III"
    reference:
      min: 8.8
      max: 10.6

  - name: "URIC ACID"
    test_category: RENAL
    category: renal
    unit: "mg/dL"
    methodology: "URICASE/PEROXIDASE"
    reference:
      male:
        min: 4.2
        max: 7.3
      female:
        min: 2.6
        max: 6.0

  - name: "eGFR"
    test_category: RENAL
    category: renal
    unit: "mL/min/1.73m²"
    methodology: "2021 CKD EPI EQUATION"
    scale:
      - { min: 90, label: "Normal" }
      - { min: 60, max: 89, label: "Mild Decrease" }
      - { min: 45, max: 59, label: "Mild to Moderate Decrease" }
      - { min: 30, max: 44, label: "Moderate to Severe Decrease" }
      - { min: 15, max: 29, label: "Severe Decrease" }
      - { max: 15, label: "Kidney Failure" }

  # ============================================================================
  # LIPID PANEL
  # ============================================================================
  - name: "TOTAL CHOLESTEROL"
    test_category: LIPID
    category: lipid_panel
    unit: "mg/dL"
    methodology: "ENZYMATIC"
    scale:
      - { max: 200, label: "Desirable" }
      - { min: 200, max: 239, label: "Borderline High" }
      - { min: 240, label: "High" }

  - name: "HDL CHOLESTEROL - DIRECT"
    test_category: LIPID
    category: lipid_panel
    unit: "mg/dL"
    methodology: "DIRECT ENZYMATIC"
    scale:
      - { max: 40, label: "Low" }
      - { min: 60, label: "High (Optimal)" }
    reference:
      min: 40
      max: 60

  - name: "LDL CHOLESTEROL - DIRECT"
    test_category: LIPID
    category: lipid_panel
    unit: "mg/dL"
    methodology: "DIRECT MEASURE"
    scale:
      - { max: 100, label: "Optimal" }
      - { min: 100, max: 129, label: "Near Optimal" }
      - { min: 130, max: 159, label: "Borderline High" }
      - { min: 160, max: 189, label: "High" }
      - { min: 190, label: "Very High" }

  - name: "TRIGLYCERIDES"
    test_category: LIPID
    category: lipid_panel
    unit: "mg/dL"
    methodology: "ENZYMATIC"
    scale:
      - { max: 150, label: "Normal" }
      - { min: 150, max: 199, label: "Borderline High" }
      - { min: 200, max: 499, label: "High" }
      - { min: 500, label: "Very High" }

  - name: "VLDL CHOLESTEROL"
    test_category: LIPID
    category: lipid_panel
    unit: "mg/dL"
    methodology: "CALCULATED"
    reference:
      min: 5
      max: 40

  - name: "NON-HDL CHOLESTEROL"
    test_category: LIPID
    category: lipid_panel
    unit: "mg/dL"
    methodology: "CALCULATED"
    reference:
      max: 160

  - name: "TC / HDL CHOLESTEROL RATIO"
    test_category: LIPID
    category: lipid_panel
    unit: "Ratio"
    methodology: "CALCULATED"
    reference:
      min: 3.0
      max: 5.0

  - name: "LDL / HDL RATIO"
    test_category: LIPID
    category: lipid_panel
    unit: "Ratio"
    methodology: "CALCULATED"
    reference:
      min: 1.5
      max: 3.5

  - name: "HDL / LDL RATIO"
    test_category: LIPID
    category: lipid_panel
    unit: "Ratio"
    methodology: "CALCULATED"
    reference:
      min: 0.4

  - name: "TRIG / HDL RATIO"
    test_category: LIPID
    category: lipid_panel
    unit: "Ratio"
    methodology: "CALCULATED"
    reference:
      max: 3.12

  - name: "APOLIPOPROTEIN - A1 (APO-A1)"
    test_category: LIPID
    category: lipid_panel
    unit: "mg/dL"
    methodology: "IMMUNOTURBIDIMETRY"
    reference:
      male:
        min: 86
        max: 152
      female:
        min: 94
        max: 162

  - name: "APOLIPOPROTEIN - B (APO-B)"
    test_category: LIPID
    category: lipid_panel
    unit: "mg/dL"
    methodology: "IMMUNOTURBIDIMETRY"
    reference:
      male:
        min: 56
        max: 145
      female:
        min: 53
        max: 138

  - name: "APO B / APO A1 RATIO"
    test_category: LIPID
    category: lipid_panel
    unit: "Ratio"
    methodology: "CALCULATED"
    reference:
      male:
        min: 0.40
        max: 1.26
      female:
        min: 0.38
        max: 1.14

  # ============================================================================
  # IRON PROFILE
  # ============================================================================
  - name: "IRON"
    test_category: IRON
    category: blood
    unit: "µg/dL"
    methodology: "FERROZINE"
    reference:
      male:
        min: 65
        max: 175
      female:
        min: 50
        max: 170

  - name: "TOTAL IRON BINDING CAPACITY (TIBC)"
    test_category: IRON
    category: blood
    unit: "µg/dL"
    methodology: "SPECTROPHOTOMETRIC"
    reference:
      male:
        min: 225
        max: 535
      female:
        min: 215
        max: 535

  - name: "% TRANSFERRIN SATURATION"
    test_category: IRON
    category: blood
    unit: "%"
    methodology: "CALCULATED"
    reference:
      min: 13
      max: 45

  - name: "FERRITIN"
    test_category: IRON
    category: blood
    unit: "ng/mL"
    methodology: "C.M.I.A"
    reference:
      male:
        min: 21.81
        max: 274.66
      female:
        min: 4.63
        max: 204.00

  - name: "UNSAT. IRON-BINDING CAPACITY (UIBC)"
    test_category: IRON
    category: blood
    unit: "µg/dL"
    methodology: "SPECTROPHOTOMETRIC"
    reference:
      min: 162
      max: 368

  # ============================================================================
  # LIVER FUNCTION
  # ============================================================================
  - name: "ALKALINE PHOSPHATASE"
    test_category: LIVER
    category: liver
    unit: "U/L"
    methodology: "MODIFIED IFCC"
    reference:
      min: 45
      max: 129

  - name: "BILIRUBIN - TOTAL"
    test_category: LIVER
    category: liver
    unit: "mg/dL"
    methodology: "DIAZONIUM SALT DPD"
    reference:
      min: 0.3
      max: 1.2

  - name: "BILIRUBIN - DIRECT"
    test_category: LIVER
    category: liver
    unit: "mg/dL"
    methodology: "DIAZONIUM SALT DPD"
    reference:
      max: 0.2

  - name: "BILIRUBIN (INDIRECT)"
    test_category: LIVER
    category: liver
    unit: "mg/dL"
    methodology: "CALCULATED"
    reference:
      max: 0.9

  - name: "GAMMA GLUTAMYL TRANSFERASE (GGT)"
    test_category: LIVER
    category: liver
    unit: "U/L"
    methodology: "MODIFIED IFCC"
    reference:
      max: 55

  - name: "ASPARTATE AMINOTRANSFERASE (SGOT)"
    test_category: LIVER
    category: liver
    unit: "U/L"
    methodology: "IFCC"
    reference:
      max: 35

  - name: "ALANINE TRANSAMINASE (SGPT)"
    test_category: LIVER
    category: liver
    unit: "U/L"
    methodology: "IFCC"
    reference:
      max: 45

  - name: "SGOT / SGPT RATIO"
    test_category: LIVER
    category: liver
    unit: "Ratio"
    methodology: "CALCULATED"
    reference:
      max: 2

  - name: "PROTEIN - TOTAL"
    test_category: LIVER
    category: liver
    unit: "gm/dL"
    methodology: "BIURET"
    reference:
      min: 5.7
      max: 8.2

  - name: "ALBUMIN - SERUM"
    test_category: LIVER
    category: liver
    unit: "gm/dL"
    methodology: "BCG COLORIMETRIC"
    reference:
      min: 3.2
      max: 4.8

  - name: "SERUM GLOBULIN"
    test_category: LIVER
    category: liver
    unit: "gm/dL"
    methodology: "CALCULATED"
    reference:
      min: 2.5
      max: 3.4

  - name: "SERUM ALB/GLOBULIN RATIO"
    test_category: LIVER
    category: liver
    unit: "Ratio"
    methodology: "CALCULATED"
    reference:
      min: 0.9
      max: 2.0

  # ============================================================================
  # ELECTROLYTES
  # ============================================================================
  - name: "SODIUM"
    test_category: ELECTROLYTE
    category: electrolytes
    unit: "mmol/L"
    methodology: "ISE - INDIRECT"
    reference:
      min: 136
      max: 145

  - name: "POTASSIUM"
    test_category: ELECTROLYTE
    category: electrolytes
    unit: "mmol/L"
    methodology: "ISE - INDIRECT"
    reference:
      min: 3.5
      max: 5.1

  - name: "CHLORIDE"
    test_category: ELECTROLYTE
    category: electrolytes
    unit: "mmol/L"
    methodology: "ISE - INDIRECT"
    reference:
      min: 98
      max: 107

  - name: "MAGNESIUM"
    test_category: ELECTROLYTE
    category: electrolytes
    unit: "mg/dL"
    methodology: "XYLIDYL BLUE"
    reference:
      min: 1.9
      max: 3.1

  # ============================================================================
  # THYROID
  # ============================================================================
  - name: "TOTAL TRIIODOTHYRONINE (T3)"
    test_category: THYROID
    category: thyroid
    unit: "ng/dL"
    methodology: "C.L.I.A"
    reference:
      min: 60
      max: 200

  - name: "TOTAL THYROXINE (T4)"
    test_category: THYROID
    category: thyroid
    unit: "µg/dL"
    methodology: "C.L.I.A"
    reference:
      min: 4.5
      max: 12.0

  - name: "TSH ULTRASENSITIVE"
    test_category: THYROID
    category: thyroid
    unit: "µIU/mL"
    methodology: "C.L.I.A"
    reference:
      min: 0.55
      max: 4.78

  # ============================================================================
  # MINERALS
  # ============================================================================
  - name: "SERUM COPPER"
    test_category: ELEMENTS
    category: minerals
    unit: "µg/dL"
    methodology: "3,5-DIBR-PAESA"
    reference:
      male:
        min: 63.5
        max: 150
      female:
        min: 80
        max: 155

  - name: "SERUM ZINC"
    test_category: ELEMENTS
    category: minerals
    unit: "µg/dL"
    methodology: "NITRO-PAPS"
    reference:
      min: 52
      max: 286

  # ============================================================================
  # PANCREAS
  # ============================================================================
  - name: "AMYLASE"
    test_category: PANCREAS
    category: metabolic
    unit: "U/L"
    methodology: "ENZYMATIC COLORIMETRIC"
    reference:
      min: 28
      max: 100

  - name: "LIPASE"
    test_category: PANCREAS
    category: metabolic
    unit: "U/L"
    methodology: "ENZYMATIC COLORIMETRIC"
    reference:
      min: 5.6
      max: 51.3

  # ============================================================================
  # URINE - DIABETES SCREEN
  # ============================================================================
  - name: "URINARY MICROALBUMIN"
    test_category: URINE DIABETES
    category: urine
    unit: "µg/mL"
    methodology: "IMMUNOTURBIDIMETRY"
    reference:
      max: 25

  - name: "CREATININE - URINE"
    test_category: URINE DIABETES
    category: urine
    unit: "mg/dL"
    methodology: "JAFFE"
    reference:
      male:
        min: 39
        max: 259
      female:
        min: 28
        max: 217

  - name: "URI. ALBUMIN/CREATININE RATIO"
    test_category: URINE DIABETES
    category: urine
    unit: "µg/mg"
    methodology: "CALCULATED"
    reference:
      max: 30

  # ============================================================================
  # URINOGRAM - Physical & Chemical
  # ============================================================================
  - name: "URINE COLOUR"
    test_category: URINOGRAM
    category: urine
    unit: "-"
    methodology: "VISUAL"
    reference:
      expected: "PALE YELLOW"

  - name: "URINE APPEARANCE"
    test_category: URINOGRAM
    category: urine
    unit: "-"
    methodology: "VISUAL"
    reference:
      expected: "CLEAR"

  - name: "URINE SPECIFIC GRAVITY"
    test_category: URINOGRAM
    category: urine
    unit: "-"
    methodology: "pKa CHANGE"
    reference:
      min: 1.003
      max: 1.030

  - name: "URINE PH"
    test_category: URINOGRAM
    category: urine
    unit: "-"
    methodology: "pH INDICATOR"
    reference:
      min: 5
      max: 8

  - name: "URINARY PROTEIN"
    test_category: URINOGRAM
    category: urine
    unit: "mg/dL"
    methodology: "PEI"
    reference:
      expected: "ABSENT"

  - name: "URINARY GLUCOSE"
    test_category: URINOGRAM
    category: urine
    unit: "mg/dL"
    methodology: "GOD-POD"
    reference:
      expected: "ABSENT"

  - name: "URINE KETONE"
    test_category: URINOGRAM
    category: urine
    unit: "mg/dL"
    methodology: "NITROPRUSSIDE"
    reference:
      expected: "ABSENT"

  - name: "URINARY BILIRUBIN"
    test_category: URINOGRAM
    category: urine
    unit: "mg/dL"
    methodology: "DIAZO COUPLING"
    reference:
      expected: "ABSENT"

  - name: "UROBILINOGEN"
    test_category: URINOGRAM
    category: urine
    unit: "mg/dL"
    methodology: "DIAZO COUPLING"
    reference:
      max: 0.2

  - name: "BILE SALT"
    test_category: URINOGRAM
    category: urine
    unit: "-"
    methodology: "HAYS SULPHUR"
    reference:
      expected: "ABSENT"

  - name: "BILE PIGMENT"
    test_category: URINOGRAM
    category: urine
    unit: "-"
    methodology: "EHRLICH REACTION"
    reference:
      expected: "ABSENT"

  - name: "URINE BLOOD"
    test_category: URINOGRAM
    category: urine
    unit: "-"
    methodology: "PEROXIDASE REACTION"
    reference:
      expected: "ABSENT"

  - name: "NITRITE"
    test_category: URINOGRAM
    category: urine
    unit: "-"
    methodology: "DIAZO COUPLING"
    reference:
      expected: "ABSENT"

  - name: "LEUCOCYTE ESTERASE"
    test_category: URINOGRAM
    category: urine
    unit: "-"
    methodology: "ESTERASE REACTION"
    reference:
      expected: "ABSENT"

  # ============================================================================
  # URINOGRAM - Microscopic
  # ============================================================================
  - name: "MUCUS"
    test_category: URINOGRAM
    category: urine
    unit: "-"
    methodology: "MICROSCOPY"
    reference:
      expected: "ABSENT"

  - name: "URINE RBC"
    test_category: URINOGRAM
    category: urine
    unit: "cells/HPF"
    methodology: "MICROSCOPY"
    reference:
      min: 0
      max: 5

  - name: "URINARY LEUCOCYTES (PUS CELLS)"
    test_category: URINOGRAM
    category: urine
    unit: "cells/HPF"
    methodology: "MICROSCOPY"
    reference:
      min: 0
      max: 5

  - name: "EPITHELIAL CELLS"
    test_category: URINOGRAM
    category: urine
    unit: "cells/HPF"
    methodology: "MICROSCOPY"
    reference:
      min: 0
      max: 5

  - name: "CASTS"
    test_category: URINOGRAM
    category: urine
    unit: "-"
    methodology: "MICROSCOPY"
    reference:
      expected: "ABSENT"

  - name: "CRYSTALS"
    test_category: URINOGRAM
    category: urine
    unit: "-"
    methodology: "MICROSCOPY"
    reference:
      expected: "ABSENT"

  - name: "BACTERIA"
    test_category: URINOGRAM
    category: urine
    unit: "-"
    methodology: "MICROSCOPY"
    reference:
      expected: "ABSENT"

  - name: "YEAST"
    test_category: URINOGRAM
    category: urine
    unit: "-"
    methodology: "MICROSCOPY"
    reference:
      expected: "ABSENT"

  - name: "PARASITE"
    test_category: URINOGRAM
    category: urine
    unit: "-"
    methodology: "MICROSCOPY"
    reference:
      expected: "ABSENT"

  # ============================================================================
  # BODY MEASUREMENTS
  # ============================================================================
  - name: "WEIGHT"
    test_category: BODY
    category: body
    unit: "kg"

  - name: "HEIGHT"
    test_category: BODY
    category: body
    unit: "cm"

  - name: "BMI"
    test_category: BODY
    category: body
    unit: "kg/m²"
    scale:
      - { max: 18.5, label: "Underweight" }
      - { min: 18.5, max: 24.9, label: "Normal" }
      - { min: 25, max: 29.9, label: "Overweight" }
      - { min: 30, label: "Obese" }

  # ============================================================================
  # VITALS
  # ============================================================================
  - name: "HEART RATE"
    test_category: VITALS
    category: vitals
    unit: "bpm"
    reference:
      min: 60
      max: 100

  - name: "BLOOD PRESSURE SYSTOLIC"
    test_category: VITALS
    category: vitals
    unit: "mmHg"
    scale:
      - { max: 120, label: "Normal" }
      - { min: 120, max: 129, label: "Elevated" }
      - { min: 130, max: 139, label: "High Blood Pressure Stage 1" }
      - { min: 140, label: "High Blood Pressure Stage 2" }

  - name: "BLOOD PRESSURE DIASTOLIC"
    test_category: VITALS
    category: vitals
    unit: "mmHg"
    scale:
      - { max: 80, label: "Normal" }
      - { min: 80, max: 89, label: "High Blood Pressure Stage 1" }
      - { min: 90, label: "High Blood Pressure Stage 2" }

  - name: "SPO2"
    test_category: VITALS
    category: vitals
    unit: "%"
    reference:
      min: 95
      max: 100

  - name: "BODY TEMPERATURE"
    test_category: VITALS
    category: vitals
    unit: "°C"
    reference:
      min: 36.1
      max: 37.2

  # ============================================================================
  # ACTIVITY
  # ============================================================================
  - name: "STEPS"
    test_category: ACTIVITY
    category: activity
    unit: "steps"

  - name: "CALORIES BURNED"
    test_category: ACTIVITY
    category: activity
    unit: "kcal"